Researchers Developed New Technology for cryo-structured Light Illumination and Electron Microscopy Correlation Imaging

Cryo-electron tomography (cryo-ET) for in situ structure analysis is a key technique for studying the in situ high-resolution structure of biomacromolecular complexes and their interactions. However, limited by the penetration ability of the electron beam, it is necessary to use the focused ion beam (cryo-FIB) to thin the cell and tissue samples into thin slices […]

High-resolution structure of a key bacterial enzyme: Aid in the fight against antibiotic resistance

A team of scientists from around the world, including from Trinity College Dublin, has obtained high-resolution structural insights into a key bacterial enzyme, which may help chemists design new drugs to inhibit it, thereby inhibiting disease-causing bacteria. Their work is important amid growing concerns about rising antibiotic resistance.   The scientists, led by Martin Caffrey, […]

Lifeasible Released a Platform Based on High-throughput Plant Phenotyping

Lifeasible, one of the innovating plant biotechnology companies, provides various plant physiological trait analysis services under normal and stress conditions. Now, the company releases a state-of-the-art platform based on high-throughput plant phenotyping that offers methods and techniques for automated trait sensing, data acquisition, and data analysis.   When it comes to breeding, gene mapping, crop […]

Protein Strongly Linked to Age-related Vision Loss Uncovered

Recently, research led by Dr. Francesca Marassi, a professor at Sanford Burnham Prebith, is helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of age-related vision loss. The study, recently published in Biophysics, describes the flexible structure of a key blood protein that is associated with macular degeneration and other age-related […]

Interleukin-18 Signaling Pathway Promotes Activation of Hepatic Stellate Cells in Mouse Liver Fibrosis

The cytokine interleukin 18 (IL-18) was originally described as an interferon gamma (IFNγ) – inducible pro-inflammatory factor in septic shock models, which stimulates T-cell  proliferation. Like IL-1β, IL-18 belongs to the IL-1 superfamily and is synthesized as a biologically active 24-kDa precursor protein (pro-IL-18) that lacks the signal peptide required for secretion. An intracellular cysteine […]